Interestingly, total chemerin was found to be increased in RA serum, although it was recently revealed using a proteomics approach that mainly 155A, 156F, and 157S chemerin isoforms are present in RA serum, which is different from the distribution in polycystic ovary syndrome, also showing increased total chemerin levels [79]. The gene discussed is RARRES2; the disease is polycystic ovary syndrome.