Based on these results, in 2018 the FDA granted accelerated approval to pembrolizumab in the third line treatment of recurrent GC or GEJC that overexpresses PD-L1 with a Combined Positive Score [CPS] ≥ 10), as determined by a U.S. Food and Drug Administration (FDA)-approved test, with disease progression after one or more prior lines of systemic therapy as identified in KEYNOTE-181. The gene discussed is CD274; the disease is gastric cancer.