The ATTRACTION-2 phase III trial found that nivolumab (anti-PD-1) improved overall survival (OS; 5.3 vs. 4.1 months in the placebo group, p < 0.0001) in heavily pretreated GC or gastroesophageal junction cancer (GEJC) regardless of PD-L1 expression [51]. Here, CD274 is linked to gastric cancer.