AQP1 and malignant colon neoplasm: AqB013, which blocks monomeric water pores, and AqB011, which blocks the AQP1 central pore, individually reduced invasion and migration in colon cancer cell lines, and together showed a synergist increase in anti-migration efficacy [71,176,187], suggesting AQP1 enhancement of cell motility depends on both water and ion channel functions.