AQP1 and metastatic malignant neoplasm in the lymph nodes: AQP1 levels in clinical cases positively correlated with histological grade, tumor size, lymph node metastasis, and distant metastasis; high AQP1 expression was associated with poor prognosis, increased recurrence, and a higher death rate within 5 years as compared to patients with low AQP1 expression in breast cancers [104].