Inadequate blood flow and poor clearance of metabolic waste from tumor masses result in hypoxia, triggering transcription of growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor-β, and platelet-derived growth factor hypoxia induced factor-1 (HIF-1) that in turn induce angiogenesis, the formation of new blood vessels [77]. This evidence concerns the gene VEGFA and neoplasm.