Upregulation of AQP3 in prostate cancer cells contributes to tumor invasiveness by stimulating MEK-Erk1/2 (MAPK) pathway, and knockdown of AQP3 reduced tumor growth by blocking the same pathway [122], suggesting inhibition of AQP3 is a target of interest for developing potential treatments of prostate cancer. This evidence concerns the gene MAPK3 and prostate carcinoma.