Although sleep disorders are recognized as correlating with anxiety, depression, and attention and aggression problems, a direct correlation with autism core features is debated [23,33], and a reciprocal influence can be explained as epiphenomena of a common neurobiological basis, which may reside in altered neurotransmitter metabolism [34], clock gene expression, or melatonin metabolism [35]. The gene discussed is CLOCK; the disease is depressive symptom measurement.