In CKD-associated intestinal inflammation an increase in iNOS expression was also reported [44] and intestinal inflammation is also characterized by an increased nitric oxide (NO) release and nitrotyrosine formation, a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide, is considered a marker of NO-dependent oxidative stress. This evidence concerns the gene NOS2 and chronic kidney disease.