Regarding exosome proteins, the most important nodes in the protein interaction network were related to metabolism (aldehyde reductase), endocytosis (heat shock proteins and members of RAS oncogene family) and pathways related to cell adhesion and cancer (catenin alpha 1 and members of the RAS oncogene family) (Figure S2 and Table S2). This evidence concerns the gene CTNNA1 and cancer.