IL6 and Hyperglycemia: Notably, proteins were also involved in the advanced glycation end products (AGEs) signaling pathway, which is related to aging and, under certain pathological conditions, such as hyperglycemia, promotes the expression of proinflammatory cytokines such as IL-1, IL-6 and TNF-α and a variety of genes including vascular cell adhesion protein 1 (VCAM-1), tissue factor, vascular endothelial growth factor (VEGF) and advanced glycation end products (RAGE) receptor [59,60].