TIMP1 and Hepatic fibrosis: The EVs alleviated liver fibrosis and inflammation by decreasing expression of fibrosis-related proteins (alpha smooth muscle actin (α-SMA), collagen 1a1 (Col1a1), and cellular communication network factor (CCN2)) and inflammatory chemokines ((chemokine (C-C motif) ligand 3 (CCL3), CCL5, CCL12, tissue inhibitor of metallopeptidase-1 (TIMP-1), and triggering receptor expressed on myeloid cells-1 (TREM-1)) in a CCl4-induced hepatic fibrosis mouse model [114].