EVs from human amnion-derived MSCs (AM-MSCs) significantly reduced expression of inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1, and TGF-β) and M1 macrophage marker proteins (CD68 and CD11c) in the liver tissue of rats in which nonalcoholic steatohepatitis (NASH) had been induced by a high-fat diet (HFD). The gene discussed is IL6; the disease is metabolic dysfunction-associated steatohepatitis.