Evaluation of multiplexed biomarkers for assessment of CSF infiltration in pediatric ALL has been attempted for matrix metalloproteinase 9 (MMP-9), monocyte chemotactic protein (CCL-2), soluble vascular cell adhesion molecule-1 (sVCAM-1), interferon gamma (IFN-γ), and inducible protein 10 [34]. The gene discussed is IFNG; the disease is acute lymphoblastic leukemia.