ACTA1 and cancer: In an in vitro co-culture model, ROS derived from cancer cells (MCF-7 cells) induced autophagy in fibroblasts and consequently reduced the expression of Caveolin-1 (Cav-1), which led to the development of myofibroblast characteristics (i.e., upregulation of α-SMA, calponin, and vimentin) [153,154,155].