In addition, down-regulation of the ROS scavenger methionine sulfoxide reductase A (MsrA), has been associated with advanced cancer in human breast cancer tissues, and the same study indicated that increased ROS production by MsrA knockout in a TNBC cell line (MDA-MB-231) led to a more aggressive phenotype in both 3D-culture and tumor xenograft models [126]. The gene discussed is MSRA; the disease is breast cancer.