Linder et al. complexed anti-STAT3 siRNA with a polyethylenimine (PEI) and phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine liposomal conjugate and found it to mediate STAT3 inhibition in glioma cells, although in vivo no significant growth inhibition was observed, and tumoral STAT3 inhibition was quite heterogeneous upon histopathologic examination [230]. The gene discussed is STAT3; the disease is central nervous system cancer.