STAT3 and central nervous system cancer: Having initially found STAT3-inhibitory miR-124 expression to be significantly downregulated in gliomas compared to normal brain, Wei et al. demonstrated that exogenously administered miR-124 induced secretion of proinflammatory cytokines from GSCs, promoted CD8+ T cell effector with decreased Treg function, and led to immune-mediated growth inhibition in a murine model of glioma [228].