For eCC, the expression of CD44 (p = 0.043), for iCC the expression of CD44 (p = 0.026), and Notch1 (p < 0.001), and for PDAC the expression of ADAM17 (p = 0.008), CD44 (p = 0.012), Notch1 (p = 0.012), and Notch4 (p = 0.008) was significantly higher in malignant tissue. Here, NOTCH4 is linked to intrahepatic cholangiocarcinoma.