In this regard, NHERF-1 loss at the cell membrane in tumor specimens could be associated with the acquisition of features that are typical of epithelial–mesenchymal transition (EMT), a process whereby cells lose their epithelial characteristics such as polarity and cell–cell contact and acquire mesenchymal features during the progression of several tumors including prostate cancer [60]. The gene discussed is NHERF1; the disease is prostate cancer.