Likewise, a prospective study with mean follow-up of 6.2 years, conducted in 2009 by Hu et al. in 625 participants, confirmed the inverse correlation between serum IGFBP2, obesity and adiposity, since higher serum IGFBP2 are associated with lower adiposity and decreased glucose tolerance [44]. This evidence concerns the gene IGFBP2 and obesity due to melanocortin 4 receptor deficiency.