Regarding the role of IGFBP2 in type 2 diabetes, Rajpathak et al. (2012) found in 742 type 2 diabetes patients and 742 matched control subjects, that IGFBP2 concentration was decreased in type 2 diabetes patients, in comparison with control participants, and higher serum IGFBP2 was associated with lower risk of type 2 diabetes [61]. The gene discussed is IGFBP2; the disease is type 2 diabetes mellitus.