IGFBP2 and metabolic dysfunction-associated steatohepatitis: Additionally, another study conducted by Ahrens et al. (2013) evaluated the DNA methylation analysis in 45 nonalcoholic fatty liver (NASH) patients, and found that IGFBP2 locus was hypermethylated in NASH, suggesting a potential role in metabolic disorders at the epigenetic levels [104].