Recently, Wittenbecher et al. (2019) showed that IGFBP2 was associated with lower risk of type 2 diabetes in 755 cases versus 2778 controls, and DNA methylation of the IGFBP2 gene was also associated with higher type 2 diabetes risk, suggesting an epigenetic alteration of the IGFBP2 gene in the type 2 diabetes context [65]. This evidence concerns the gene IGFBP2 and type 2 diabetes mellitus.