IGFBP2 and obesity due to melanocortin 4 receptor deficiency: In the same years, Zhang et al. showed that IGFBP2 DNA methylation levels in visceral adipose tissue were increased in obese subjects, and increased when compared to the IGFBP2 DNA methylation in subcutaneous adipose tissue, irrespective of obesity [50], suggesting a specific-depot epigenetic alteration in the IGFBP2 regulation.