On the other hand, the phosphorylated IGF1R can also induce the recruitment of SHC adaptor protein (Shc), growth factor receptor-bound protein 2 (Grb2), Son of Sevenless (SOS), and rat sarcoma (Ras), which leads to stimulate the mitogen activated protein kinase (MAPK) signalling pathway. This evidence concerns the gene GRB2 and sarcoma.