Such anti-HBc positivity rates in the vaccinated generation, together with relatively low HBsAg prevalence and the absence of a self-reported history of jaundice or liver disease, suggest that a significant proportion had a self-limited subclinical infection in vaccinated individuals, i.e., an ongoing circulation of HBV in the vaccinated generation born between 1998 and 2019. The gene discussed is KRT88P; the disease is Jaundice.