It was shown that all the synthesized hybrid molecules exhibited high cytotoxicity against a panel of five tumor cell lines (Jurkat, K562, HEK293, HeLa, and U937) as compared with the original lithocholic acid and also, possibly, to a small extent affected topoisomerase II, initiated mitochondrial apoptosis in Jurkat tumor cells, thus causing loss of cytochrome C and activation of caspases. The gene discussed is CYCS; the disease is neoplasm.