Cutaneous melanoma has been categorized into four major genomic subtypes: v-Raf murine sarcoma viral oncogene homolog B (BRAF) mutant (52%), neuroblastoma RAS viral oncogene homolog (NRAS) mutant (28%), neurofibromin 1 (NF1) (14%) mutant, and triple-wildtype (6%), the latter characterized by a lack of BRAF, NRAS, or NF1 mutations but enrichment of tyrosine kinase (KIT) mutations [2]. The gene discussed is NF1; the disease is cutaneous melanoma.