A recent study highlighted a compound called NSC130362, which belongs to the class of 1,4-naphthoquinones (NQs) and has vibrant pharmacological properties [70]; it has been shown to possess anti-cancer effects, including anti-proliferative and anti-angiogenesis activity [71,72], suppress glycolysis and mitochondrial function [73], and inhibit NF-κB signaling [74]. Here, NFKB1 is linked to cancer.