DNM1L and breast cancer: In breast cancer, increased mitochondrial fragmentation intensifies the capabilities of breast cancer cells to metastasize by activating Drp1 or silencing Mfns [8].The imbalance of Drp1/Mfn expression has also been found to cause additional mitochondrial fission and impaired mitochondrial fusion inhuman lung cancer cell lines, which is a key process for cell cycle progression [25].In addition, cancer cells are involved in the mitochondrial respiration chain to gain an obvious increase in ATP production [26].