TGFB1 and hepatocellular carcinoma: The depleted mtDNA induces mitochondrial dysfunction and further triggers EMT induction, the prostate and breast adenocarcinoma cells show mesenchymal phenotypes with TGF-β overexpression [38].Moreover, in hepatocellular carcinoma cells, mtDNA depletion induces EMT via TGF-β/SMAD/SNAIL signaling [39].