IQGAP1 and pachyonychia congenita: However, we provide comprehensive evidence suggesting a potential tumor suppressive role of IQGAP1 in PC, which includes (1) downregulation of IQGAP1 in PCs vs. prostate tissues, mPC vs. primary PCs, and CRPC vs. androgen-sensitive PCs; (2) the association of IQGAP1 reduction with PC biochemical recurrence in two independent cohorts, MSKCC and TCGA PanCancer; and (3) the enrichment of pathways or processes underlined by cytoskeleton dynamics (Figure 5, Table 1).