For instance, HAGHL (Hydroxyacylglutathione Hydrolase Like), LCN12 (Lipocalin 12), DCST2 (DC-STAMP Domain Containing 2), and PRR7 (Proline Rich 7, Synaptic) not only significantly predicts PC recurrence but also remain risk factor status after adjusting for age at diagnosis, WHO prostate cancer grade, margin status, and tumor stage (Table 4). This evidence concerns the gene PRR7 and pachyonychia congenita.