EMSA was carried out using oligonucleotide probes (OL1–8) covering the −204 to +2 region of the CPR in non-neuronal cells such as fetal rat skin keratinocyte FRSK and rat fibroblast 3Y1 and neuronal cells such as rat adrenal pheochromocytoma PC12 and human neuroblast IMR32 to study the binding properties of Stx1a–CPR correlating to the Stx1a expression. This evidence concerns the gene STX1A and adrenal gland pheochromocytoma.