Accordingly, MT-RNR1 709A was significantly correlated with overall survival in the subgroups of age ≤65 y, female sex, cirrhosis positivity, HBV-related HCC, AFP ≥ 400 ng/mL, bilirubin < 1.2 mg/dL, ALT < 41 IU/L, AST ≥ 31 IU/L, PT < 12 s, alcoholism-negative, primary tumor (only 1 tumor), tumor size ≥ 5 cm, histology grade 3-4, microvascular invasion negative, and macrovascular invasion negative group. Here, F2 is linked to alcohol drinking.