Single nucleotide polymorphisms (SNPs) in IFIH1/MDA5 have been linked to autoimmune disorders, type 1 diabetes (T1D), psoriasis, rheumatoid arthritis, vitiligo, multiple sclerosis (MS), and Systemic Lupus Erythematosus (SLE) [149,150,151,152,153,154,155]. The gene discussed is IFIH1; the disease is systemic lupus erythematosus.