Human inborn errors in select genes can underlie type I interferonopathies, for example Aicardi-Goutières syndrome is characterized by genetic mutations in three-prime-repair exonuclease 1 (TREX1), SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) and interferon-induced with helicase C domain 1 (IFIH1) among others [321]. Here, TREX1 is linked to Aicardi-Goutières syndrome.