Moreover, higher TIL levels have been associated with increased pCR rates after neoadjuvant chemotherapy also in luminal-like BC; however, survival analysis from a large study pooling individual patient data from several neoadjuvant trials revealed a counterintuitive association between higher TILs and shorter OS in the luminal-like/HER2-negative BC subgroup [8]. This evidence concerns the gene ERBB2 and breast cancer.