One study [105] compared ADC- and FA-derived measures, obtained with a “hotspot” manual ROI approach (after the visual identification of low-ADC and high-FA areas), and it reported similar capability of IDH-prediction (AUC ranging 0.76–0.94) for LGG, whereas only ADC (not FA) predicted IDH-status in GBM (AUC 0.66–0.70). This evidence concerns the gene IDH1 and glioblastoma.