Thus, the interactions of DNMT1 with the aforementioned proteins, i.e., MBPs, DNMT3A and DNMT3B, HDAC1 and HDAC2, and SUV39B may result in transcriptional repression of many genes in cancer cells, mainly TSGs, thereby stabilizing the heterochromatic state [32]. The gene discussed is DNMT3B; the disease is cancer.