EPS8L2 and cancer: More recently, Lee et al. identified 56 urinary EV proteins upregulated in UBC samples and advanced four for further validation: Mucin 1, a glycoprotein involved in the pathogenesis of several cancers; carcinoembryonic antigen (CEA), a glycoprotein associated with angiogenesis and immune evasion; epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2), associated with endometrial cancer; and Moesin, an ERM-family protein associated with metastasis [81].