PCA3 and Familial prostate cancer: The ExoDx Prostate IntelliScore (EPI) from Exosome Diagnostics (a Bio-Techne brand) is a urine-based test that combines ultrafiltration-based bulk EV isolation and RT-qPCR to measure expression of three genes highly upregulated in prostate cancer: PCA3 (prostate cancer antigen 3), ERG (V-ets) erythroblastosis virus E26 oncogene homologs), and SPDEF.