Common to the theme of inflammation, the top hit in baseline maternal metabolome, 2-aminoadipate, has been previously implicated in type 2 diabetes [24], as a lysine oxidation product by myeloperoxidase in inflammatory processes [25], whereas N-palmitoylglycine (top hit in third trimester maternal metabolome) may stimulate the production of nitric oxide [26], which is involved in asthma physiopathology [27]. The gene discussed is MPO; the disease is asthma.