As an example, Coffin–Siris syndromes (CSS), Nicolaides–Baraitser syndrome (NCBRS), and Chr6q25 microdeletion syndrome, commonly known as BAFopathies, which arise from SWI/SNF remodeling complex defects, share a common, highly overlapping episignature. The gene discussed is SMARCA1; the disease is Coffin-Siris syndrome.