While sLRP1 plays a potentially neuroprotective role in stroke by possibly acting as a scavenger for heme-hemopexin complexes that are found in excess in the brain after a hemorrhagic stroke, LRP1 shedding increases the permeability of the BBB during ischemic stroke, leading to cerebral edema, tissue damage, and, in some cases, hemorrhagic transformation. The gene discussed is HPX; the disease is stroke disorder.