While sLRP1 plays a potentially neuroprotective role in stroke by possibly acting as a scavenger for heme-hemopexin complexes that are found in excess in the brain after a hemorrhagic stroke, LRP1 shedding increases the permeability of the BBB during ischemic stroke, leading to cerebral edema, tissue damage, and, in some cases, hemorrhagic transformation. This evidence concerns the gene HPX and Stroke.