Mitochondrial fission is promoted, on the other hand, by DRP1 phosphorylation at Ser585 by CDK5 (cyclin-dependent kinase 5) [48], by modification of Tyr266 by the Abelson tyrosine kinase (ABL) [22], and by phosphorylation at the highly conserved Ser616 by ERK1/2 (extracellular receptor kinase 1/2), which increased mitochondrial fragmentation in human pancreatic adenocarcinoma [49]. Here, CDK5 is linked to pancreatic adenocarcinoma.