The limitations of our study are (1) the cohort size is small, and we lack an external validation cohort; therefore, our results are at risk of overfitting; (2) as the aim of this study was to evaluate the performance of urine 1H-NMR metabolomics in an Asian cohort, we did not include Caucasian patients for comparison; (3) due to the small cohort we were not able to analyze PC subgroups, e.g., PSA/Gleason Score/Metastases; and (4) In addition, we focused on the metabolites in urine. The gene discussed is KLK3; the disease is pachyonychia congenita.