APC and hereditary disease: The most important genetic disorders that confer an increased risk for CRC are hereditary non-polyposis colorectal cancer (HNPCC) [85], in which mutated genes for DNA mismatch repair result in a greatly increased CRC risk, and familial adenomatous polyposis (FAP), which in most cases is caused by mutations in the Wnt pathway gene, adenomatous polyposis coli(APC), leading to the development of hundreds or thousands of intestinal polyps with a high risk of progression to CRC [86].