Moreover, in the oleic acid supplementation in transgenic mice featured in Alzheimer’s disease pathology, it leads to the reduction in the secreting Aβ levels in amyloid precursor protein (APP) 695 transfected Cos-7 cells, but also the reduction in BACE-1 levels and presenilin levels, and has caused the amyloid plaques in the brain to reduce [56]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.