Additional supporting data regarding the strict relationship between stemness, EMT, immune-evasion and chemoresistance are provided by recent studies showing that immune-regulatory molecules such as CD200, PD-1, PD-L1 and CTLA-4 are directly involved in CSC maintenance and enrichment, activating the expression of the stemness-related genes Oct-4 and Nanog, promoting the EMT process, as well as the tumorigenicity and chemotherapy resistance of cancer cells [204,205,206]. This evidence concerns the gene CD274 and cancer.