CD133+ cells with cancer stem cell characteristics associate with vasculogenic mimicry, and a correlation has been observed between CD133+ and ALDH+ cells, vascular mimicry and tumor aggressiveness in ovarian cancer patients [176,177]; finally, ABCB5, CD133, CD271-positive melanoma cells have been found to be able to transdifferentiate to endothelial-like cells both in vitro and in vivo [178,179]. This evidence concerns the gene PROM1 and cancer.