In line with this, when oral glucose tolerance was assessed in 75 young overweight men with steatosis, HOMA-IR was the most important predictor (Odds Ratio of 3.4 compared with no steatosis) of impaired glucose tolerance, with the glucose-intolerant individuals characterized by 70% higher fasting insulin levels [84], likely related to reduced insulin clearance. The gene discussed is INS; the disease is steatosis.