INS and type 2 diabetes mellitus: In a study of lean and obese individuals with type 2 diabetes, basal HGP did not correlate with hepatic TG content, whereas HISI and the suppression of HGP during a low dose insulin infusion (240 pmol/min/m2) correlated negatively with hepatic TG [29], supporting that hepatic TG is also negatively correlated with hepatic insulin sensitivity in individuals with type 2 diabetes.