In this population, HISI was approximately 50% lower in the presence of NAFLD independently of glucose tolerance, whereas the suppression of HGP during a low-dose insulin clamp (10 mU/m2 BSA/min) was more impaired in NAFLD individuals with prediabetes/diabetes (−44%) compared with individuals without NAFLD (−61%). The gene discussed is INS; the disease is diabetes mellitus.