In conclusion, we identified ten methylation markers affecting four genes (SMOC1, KCNA4, SLC25A21, and UPP1) that are associated with glioma grade progression, and demonstrate a strong prognostic probability for patient prognosis which is also able to identify patients usually considered to be good survivors (oligodendroglioma). The gene discussed is UPP1; the disease is oligodendroglioma.