TNF and rheumatoid arthritis: On the 14th day, an increase in the concentrations of TNF-α was observed in animals with RA: 48.01 ± 11.73 pg/mL for the Humira group, 94.12 ± 9.69 pg/mL for the Cytos-11 group, and 86.15 ± 5.9 pg/mL for the control group.