Da-Huang-Gan-Cao-Tang (Daiokanzoto), a crude extracts of Rhubarb rhizomes and Glycyrrhiza roots, was thought to suppress bone resorption in periodontitis, since this medicine inhibited P. gingivalis-induced nuclear factor (NF-κB) activity, IL-6 expression and matrix metalloproteinase (MMP)-1 activity in human gingival epithelial cells and fibroblasts [19,21]. The gene discussed is IL6; the disease is periodontitis.