ACP5 and periodontitis: The present study showed that GLY extracts significantly inhibited sRANKL-induced osteoclast differentiation and decreased the expressions of osteoclast differentiation markers in vitro, and that the administration of GLY extracts for rat experimental periodontitis inhibited the ligature-induced alveolar bone resorption and significantly decreased the number of TRAP-positive osteoclasts around a ligature in the alveolar bone in vivo.