When compared to gene expression profiling studies in cultured dermal fibroblasts or skin biopsies, DLX5 was reported to be under-expressed in patients with SSc [43], while transmembrane protein 140 (TMEM140) was reported to be overexpressed in patients with SSc [43] and correlated with the modified Rodnan skin thickness score (mRSS) in dcSSc patients [47]. This evidence concerns the gene DLX5 and systemic sclerosis.