SERPINB5 and neoplasm: We wish to highlight, in the present article, an unpublished personal observation that refers to the capacity of maspin protein to mark not only the dyscohesive cells from the invasive front, referred to as tumor buds [1,2,6], but also the nuclei of those tumor cells, from the tumor-stroma interaction line, which are “at the point of budding” (Figure 1).