As maspin was isolated from Saccharomyces cerevisiae [8] and antibodies against Saccharomyces cerevisiae (ASCA) can be detected in patients with Crohn’s disease or other autoimmune disorders of the gastrointestinal tract [51,52], it might be supposed that, in patients with IBD and increase IgM and IgG ASCA, the dysregulated intestinal microbiota can occur via cytoplasm-to-nuclear translocation of the maspin protein. The gene discussed is SERPINB5; the disease is Crohn disease.