For this reason, we cannot know if maspin-mediated inflammation-dysplasia-neoplasia process depends on the immunogenic properties of maspin [28,29], the p53-maspin interraction [16,20,53], the molecular mimicry of Saccharomyces cerevisiae [51] or it is about the superposed role of the environmental stimuli in dysregulating gut microbiota and inducing IBD. Here, TP53 is linked to neoplasm.