CYBB and obesity due to melanocortin 4 receptor deficiency: The results showed that oxLDL, urinary excretion of 8-iso-PGF2α and NOX2 activity, as assessed by serum levels of sNOX2-dp, were higher in obese children than in control groups, suggesting that NOX2-generating oxidative stress may have a pathogenic role in the functional changes in obesity and hypercholesterolemia [138] (Table2).