PKM and infection: Infection of GM- and Dex-MDMs with wild-type A. fumigatus conidia (MOI = 1) resulted in differential activation of PKM2, while PKM2 was strongly triggered in GM-MDMs; activation of PKM2 in Dex-MDMs was comparable to that in M-MDMs and significantly lower than Aspergillus-exposed GM-MDMs (Figure 5A).