In the Dialysis patients Response on IV Iron with Elevated ferritin (DRIVE) study, Coyne and colleges demonstrated that an intensive IV iron administration protocol (125 mg ferric gluconate for eight HD sessions) can significantly reduce ESA dosing requirements in patients with anemia on HD who have a ferritin ≥ 500 ng/mL and TSAT ≤ 25% and are receiving adequate epoetin [51]. This evidence concerns the gene EPO and anemia (phenotype).