We found that disease severity did not correlate with the expression of PD-L1 in TIICs in either the tumor periphery or tumor center (Supplementary Figure S1), nor were there correlations between the abundantly expressed PD-1 in the TIICs in the tumor center (Figure 4A–C) or even in the much more abundantly expressed PD-1 in the peripheral TIICs (Figure 4D–F). This evidence concerns the gene PDCD1 and neoplasm.