Much like MNRR1, CHCHD10 is associated with various neurodegenerative diseases: spinal muscular atrophy (Jokela type) (SMAJ) [126], amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD) [125,127], lower motor neuron syndrome [128], and autosomal dominant mitochondrial myopathy [123]. Here, CHCHD2 is linked to lower motor neuron syndrome with late-adult onset.