CD8A and neoplasm: More specifically, (i) the disorganized network of tumor vessels hinder CD8 + T cell trafficking into the TME; (ii) VEGF interferes with the maturation of dendritic cells and thus suppresses T-cell priming; and (iii) protumoral M2-like macrophages as well as type-2, T-helper cells and regulatory T-cells (Tregs) secrete pro-angiogenic factors that accelerate uncontrolled angiogenesis and promote vascular immaturity thus creating a vicious circle [80].