INS and type 2 diabetes mellitus: Interestingly, imprinted gene expression is deregulated in subclones of stable mouse-derived MIN6 beta cells that are “poorly responsive” in terms of insulin secretion to glucose and other secretagogues compared with “highly responsive” MIN6 subclones [72], and in pancreatic islets from T2D vs non-diabetic subjects [66,70,73,74,75].