Imprinted genes play key functional roles in beta cells [57,59,60,61,62,63,64,65,66,67,69,70,71] and a disproportionate number display deregulated expression in a model of diminished glucose-stimulated insulin secretion (GSIS) [72] and in pancreatic islets from T2D patients [66,70,73,74,75]. This evidence concerns the gene INS and type 2 diabetes mellitus.