We used two primary tumors (WM983A and WM278), two melanoma metastasis (WM983B and WM1617)-originating melanoma cell line pairs, as well as four BRAF inhibitor (BRAFi: PLX4720)-resistant cell lines (WM983ABRAFiRES, WM983BBRAFiRES, WM278BRAFiRES, WM1617BRAFiRES) to define the effect of HA15 on melanoma cell viability. Here, BRAF is linked to melanoma.