As a modifier of frontotemporal lobe dementia (FTLD) risk, transmembrane protein 106b (Tmem106b) was examined in Tmem106b+/+, +/− and −/− mice, which were injected with adeno associated virus-(GGGGCC)66, and which showed no statistical differences in their Iba1 mRNA levels [96]. Here, TMEM106B is linked to semantic dementia.