Increased colocalization of CD11b with TNFα [40,43] and TNFα receptor 1 (TNFR1) [40] in the cervical spinal cord of wobbler mice was reduced with treatments of glutamate release inhibitor riluzole, an approved drug against ALS [43], and a toll-like receptor 4 (TLR4) antagonist, VB3323 [43]. This evidence concerns the gene TLR4 and amyotrophic lateral sclerosis.