On the other hand, M2-type microglia can enhance the motor neuron survival in ALS by releasing anti-inflammatory cytokines such as transforming growth factor beta (TGFβ), interleukin 4 (IL-4), interleukin 10 (IL-10), interleukin 13 (IL-13) and neurotrophins such as insulin-like growth factor (IGF-1) and brain-derived neurotrophic factor (BDNF) to repair and restore the damaged tissue [4,50]. Here, BDNF is linked to amyotrophic lateral sclerosis.