However, due to increased expression of TLR4 [100] and activating DAMPs of TLR2 [96] and 4 [94,96,100,128,129,130,131,132,133] in patients with COVID-19, Dectin-1 may participate in cross-communication with TLRs during S protein and DAMP identification and stimulation. This evidence concerns the gene TLR4 and COVID-19.