Many studies have shown DUBs involvement in the regulation of Wnt/β-catenin signaling, TGF-β (transforming growth factor-β), Akt (Protein Kinase B), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and other cancer-related pathways [33,34,35,36]. Here, NFKB1 is linked to cancer.